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KMID : 0385520080210020084
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Analytical Science & Technology
2008 Volume.21 No. 2 p.84 ~ p.92
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Analysis of caffeine in aqueous sample by hollow fiber-liquid microextraction (HF-LPME)
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In Chi-Yeon
Kim Taek-Jae
Myung Seung-Woon
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Abstract
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A method for the determination of trace amount of caffeine in urine and various drink samples using hollow fiber-liquid phase microextraction (HF-LPME) and capillary gas chromatograph/nitrogen phosphorus detector (GC/NPD) has been established. HF-LPME method has been optimized with respect to several experimental parameters including the effects of the hollow fiber length, extraction solvent, stirring mode, pH and salt concentration for the determination of caffeine from aqueous samples. The correlation coefficient of calibration curve for caffeine was 0.9994. The average recovery was 102%(n=3). The established method is feasible for the determination of trace amounts of caffeine in several aqueous sample. The limit of detection (LOD) and the limit of quantitation (LOQ) have been found to be 2.5 and 10 ng/mL, respectively. The established HF-LPME method for the analysis of caffeine from aqueous sample can be used for the determination of biological, food and environmental samples.
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KEYWORD
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HF-LPME, GC-NPD, Caffeine
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